The Gamcsik laboratory studies the metabolic dynamics in human disease with our main focus on the role the antioxidant glutathione (GSH) and associated pathways play in the initiation, progression and treatment of cancer. Metabolic dynamics reflect tissue function that results from the net contribution of all the genes, proteins and metabolites that are present in the tissue under the influence of regulatory networks and the tissue environment. Our laboratory uses novel stable isotope labeling and detection strategies to map the variation in metabolic dynamics in tissue.